• Column 27 hydrophobic drugs that are difficult to dissolve in traditional solvents or water . This effectiveness is attributed to the ILs ’ tunable polarity and ability to form specific interactions with drug molecules , disrupting existing forces that impede drug integration .
July-August . 2024 | @ green
• Column 27 hydrophobic drugs that are difficult to dissolve in traditional solvents or water . This effectiveness is attributed to the ILs ’ tunable polarity and ability to form specific interactions with drug molecules , disrupting existing forces that impede drug integration .
INNOVATIVE STRATEGIES AND FUTURE POSSIBILITIES
It is estimated that 40-70 per cent of potential drug candidates fail due to solubility-limited bioavailability ( Shukla et al ., 2023 ). This percentage highlights the importance of solubility in drug development , as poor soluble drugs may not dissolve adequately in the gastrointestinal tract , leading to suboptimal absorption and efficacy .
Apart from that , solubility also plays a crucial role in formulation development , guiding the selection and design of the appropriate dosage form . It also impacts the drug ’ s pharmacokinetics and pharmacodynamics , ultimately determining its therapeutic effect and safety profile .
To address this challenge , the pharmaceutical industry is exploring various methods to improve drug solubilities and pharmacological properties . One innovative strategy is the development of active pharmaceutical ingredients ( API-IL ), which combine distinct anionic and cationic derivatives of approved pharmaceuticals to control various pharmacological properties .
For example , pairing acyclovir ( a drug used to treat viral infections , especially herpes simplex virus infections ) with suitable complementary ions has significantly enhanced acyclovir ’ s solubility in water by more than two orders of magnitude . Such innovations improve formulation efficacy and address the challenges related to solubility and bioavailability .
OVERCOMING CHALLENGES AND ENSURING COMPLIANCE
While ILs hold great potential in halal pharmaceuticals , challenges accompany their adoption . Ensuring that ILs are not only halal but also toyyib ( not harmful to the environment or human health ) requires a thorough selection of ionic components and a stringent certification process .
Achieving these requires collaboration between chemists , halal certification bodies , and pharmaceutical companies to navigate these complexities and ensure compliance with halal standards .
BRIGHT FUTURE AHEAD Exploring ILs within the halal pharmaceutical concept showcases the boundless potential of scientific innovation . As research progresses and more halal-compliant ILs are developed , we can anticipate a new generation of halal pharmaceutical products that are effective and safe and adhere to the ethical standards valued by Muslim customers .
Islam mandates seeking treatment to safeguard health , integral to fulfilling the adh-dharuriyat al-khams ( The Five Necessities ). Investing in halal alternatives and engaging with Muslim communities can facilitate the development of pharmaceutical products that uphold Shari ’ ah principles , as reported in the hadith .
It was narrated by Abu Huraira , the Prophet said :
“ There is no disease that Allah has created , except that He also has created its treatment .” Sahih al-Bukhari 5678 ( Book 76 , Hadith 1 ) – Chapter on Medicine
This harmonious blend of science and faith paves the way for groundbreaking medical advancements . It ensures that these innovations remain deeply rooted in ethical and religious integrity , encouraging continuous search and development of medicines to cure all diseases . – @ green