IN a recent announcement, the World Health Organisation( WHO) officially recommended injectable lenacapavir( LEN) as a new Human Immunodeficiency Virus( HIV) prevention option. This marks a major shift in global guidelines. Announced at the International AIDS Society Conference( IAS 2025), LEN is the first twice-yearly injectable pre-exposure prophylaxis( PrEP) product.
With 1.3 million new HIV infections reported in 2024, global prevention efforts have stalled, making WHO’ s new guidelines timely. The burden remains highest among sex workers, LGBTQ + individuals, injecting drug users, prisoners, and youths.
“ While an HIV vaccine remains elusive, LEN is the next best thing: a long-acting antiretroviral shown in trials to prevent almost all HIV infections among those at risk,” said WHO Director-General( DG) Dr Tedros Adhanom Ghebreyesus.
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Tedros Adhanom Ghebreyesus
WHO also simplified HIV testing, removing a major access barrier by enabling community-based delivery of long-acting injectable PrEP through pharmacies, clinics, and tele-health.
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LEN, along with other WHOrecommended PrEP options like daily oral PrEP, injectable cabotegravir, and the dapivirine vaginal ring, contributes to the global effort to end the HIV epidemic. |
Currently, access to LEN outside of clinical trials is limited. Hence, WHO urged governments, donors, and global health partners to immediately implement LEN across national combination HIV prevention programmes, collecting data on uptake, adherence, and impact.
Furthermore, WHO has issued new guidance to help countries sustain HIV services amid funding cuts. The guidance outlines a stepby-step framework for countries to streamline service prioritisation, risk assessment, monitor disruptions, and system adaptations.
WHO Department of Global HIV, Hepatitis and Sexually Transmitted Infections( STI) Programmes( HHS) Director Dr Meg Doherty stressed:“ We have the tools and the knowledge to end AIDS as a public health problem. What we need now is bold implementation of these recommendations, grounded in equity and powered by communities.”
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